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Renal Excretion of Urate in Patients With Gout
C. A. NUGENT, MD;
W. D. MacDIARMID, MD;
F. H. TYLER, MD
Arch Intern Med. 1964;113(1):115-121.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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In recent years it has been shown that patients with gout usually excrete less urinary urate than do nongouty subjects whose plasma urate concentration has been elevated to the levels of patients with gout by acute loading with urate or its precursors.1-3 These observations have led some investigators to conclude that impaired renal urate excretion is a frequent cause contributing to hyperuricemia in patients with gout. More recently Yü, Berger, and Gutman 4 have reported experiments which confirmed these observations but challenged the interpretation placed upon them. They suggested that the difference observed in renal excretion between the gouty and nongouty groups was the result of the acute urate loading of the nongouty subjects rather than the result of a difference in renal urate excretion between the two groups. In support of this suggestion they interpreted their data on urate loading as showing that "gouty subjects can excrete large
. . . [Full Text PDF of this Article]
Author Affiliations
SALT LAKE CITY
From the Laboratory for the Study of Hereditary and Metabolic Disorders and the Department of Medicine, University of Utah College of Medicine.
Footnotes
Received for publication June 19, 1963; accepted July 17.
Aided in part by grants from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, United States Public Health Service, Bethesda, Md.
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