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Report of Two Cases

MICHEL E. KAHIL, MD; HERBERT L. FRED, MD; HAROLD BROWN, MD; JOYCE S. DAVIS, MD

Arch Intern Med. 1964;113(1):63-69.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1940 Sheehan ¹ called attention to six patients who developed jaundice in the third trimester of pregnancy and died within three days after delivery. The course in these cases was similar to that of fulminant hepatitis, but histologic examination of the liver revealed no hepatocellular necrosis, little or no inflammatory reaction, and many small intracytoplasmic lipid-laden vacuoles arranged about a centrally placed, normal nucleus. He considered these findings to be a distinct histologic entity which he termed "obstetric acute yellow atrophy." Others subsequently referred to it as "acute fatty metamorphosis of the liver associated with pregnancy"² and "acute fatty liver of pregnancy." ³

To date at least 39 patients with this syndrome have been described.^1-16 Eight others are known to have been studied but not reported.^2,3,5,17 The cases presented by Barry and O'Dwyer,¹⁸ Dill (case VI),¹⁹ and Cullinan (case A)¹¹ also may be . . . [Full Text PDF of this Article]

Author Affiliations
HOUSTON

Fellow in Metabolism, Department of Medicine (Dr. Kahil); Assistant Professor of Medicine and Director of Medical In-Patient Service, Department of Medicine, The Ben Taub General Hospital (Dr. Fred); Professor of Medicine, Head, Metabolic Section (Dr. Brown); Assistant Professor of Pathology (Dr. Davis).; From the departments of medicine and pathology, Jefferson Davis Hospital and Baylor University College of Medicine.

Footnotes
Received for publication July 16, 1963; accepted Aug 1.

Investigation supported by US Public Health Service training grant 2A-5063 from the National Institute of Arthritis and Metabolic Diseases.

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