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HAROLD L. ISRAEL, MD; MAURICE SONES, MD

Arch Intern Med. 1964;113(2):255-260.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A diagnosis of sarcoidosis should not be made on the basis of clinical and radiologic characteristics alone, since similar changes occur in patients with tuberculosis, histoplasmosis, and lymphoma. Until standardized and stable Kveim test materials are developed, the demonstration by biopsy of epithelioid granulomas must be regarded as essential to the diagnosis of sarcoidosis.

Sarcoidosis is, as a rule, a widely disseminated disease, so that numerous biopsy sites and methods have been successfully em- ployed. One consequence is that confusion exists as to the best methods. An example is our repeated experience of referring patients for surgical biopsy of palpable lymph nodes, only to have scalene fat pads excised in the belief that this approach afforded the greatest likelihood of demonstrating sarcoid tissue.

It appeared that an analysis of our experience with biopsy techniques in 329 patients with sarcoidosis would be of value. The diagnosis in each case was based . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Sarcoid Clinic of the Jefferson Medical College Hospital.

Footnotes
Received for publication July 23, 1963; accepted Sept 10.

This study was supported by grants from the American Thoracic Society, Medical Branch of the National Tuberculosis Association, and from the Pennsylvania Thoracic Society.

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