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WALDEMAR PRUZANSKI, MD; REUBEN ALTMAN, MD

Arch Intern Med. 1964;113(2):261-266.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Histiocytosis X, a proliferation of histiocytes of indefinite etiology, is classified into localized (eosinophilic granuloma) and diffuse, acute (Letterer-Siwe) or chronic (Hand-Schüller-Christian) varieties. The cause of such a proliferation remains unknown.¹ Inflammatory, allergic, or neoplastic origins are suggested, but as yet remain unproved.^2,3

These three forms, although clinically different, overlap each other, and various combinations or "transitional" forms producing bizarre manifestations have been described.

This report deals with a fulminant disseminated histiocytosis with predominant pulmonary pathology, which appeared in a young woman. Such a combination is exceptional. To our knowledge only one similar case has been reported in the literature.⁴

Report of a Case

A 22-year-old housewife, previously healthy, was hospitalized because of high fever, headache, weakness, and productive cough of ten days' duration. On physical examination, a severely ill, thin woman was found. The breathing was rapid and shallow and mild cyanosis was seen. Blood . . . [Full Text PDF of this Article]

Author Affiliations
ZERIFIN, ISRAEL

From the Department of Internal Medicine B, "Asaf Harofe" Government Hospital.

Footnotes
Received for publication June 27, 1963; accepted Sept 25.

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