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A 12-Month Comparison

R. R. H. LOVELL, MD; M. A. DENBOROUGH, DPhil; P. J. NESTEL, MBBS; A. J. GOBLE, MD

Arch Intern Med. 1964;113(2):267-274.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Although anticoagulants are used extensively in patients with ischemic heart disease, there is disagreement about their efficacy. The drugs used most commonly in long-term treatment in survivors of myocardial infarction are coumarins and indandiones; but heparin is also advocated, and in 1956 Engelberg, Kuhn, and Steinman reported that prolonged intermittent heparin therapy reduced the mortality rate when given to patients who had previously had a myocardial infarct.¹ In their study, patients were alternately placed in two groups. One group of 105 patients received twice-weekly subcutaneous injections of 200 mg concentrated aqueous heparin for an average of 19.7 months. The other group of 117 patients received subcutaneous isotonic saline placebo injections twice weekly for an average of 18.7 months. Over a period of therapy ranging from 1-27 months there were four deaths due to cardiovascular disease in the heparin-treated group and 21 in the saline-treated group.

This heparin regimen seemed . . . [Full Text PDF of this Article]

Author Affiliations
VICTORIA, AUSTRALIA

University of Melbourne, Department of Medicine, and the Royal Melbourne Hospital.

Footnotes
Received for publication Aug 22, 1963; accepted Sept 23.

Supported by a grant from the National Heart Foundation of Australia.

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