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A Clinical and Pathological Study of Six Cases

A. H. RUBENSTEIN, MB, BCh; C. ABRAHAMS, MB, BCh, FFP (SA); D. P. STABLES, MB, BCh; N. W. LEVIN, MB, BCh, FCP (SA)

Arch Intern Med. 1964;113(3):378-394.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Before 1960 the association of interstitial nephritis and papillary necrosis with the chronic ingestion of kilogram quantities of acetophenetidin (Phenacetin) was described almost exclusively by Swiss and Scandinavian authors. Since that date a number of authors outside of Europe have drawn attention to the possible effects of acetophenetidin, and in all probability the condition is not as rare in other countries as was formerly believed.

At present there is a great deal of controversy concerning various aspects of the relationship of acetophenetidin ingestion and renal disease. Thus, the exact role of acetophenetidin or its degradation products in the production of renal lesions is uncertain ¹; the importance of the different methods of manufacture of acetophenetidin and the resulting contaminating compounds in the pathogenesis of the renal disease is being debated ²; the specificity of the histological picture produced by prolonged ingestion of acetophenetidin is open to doubt ^3,4; the role . . . [Full Text PDF of this Article]

Author Affiliations
JOHANNESBURG, SOUTH AFRICA

Senior Research Bursar, Cardio-Pulmonary Unit of the Council for Scientific Research (Dr. Rubenstein); Lecturer in the Department of Pathology (Dr. Abrahams); Tutorial Registrar in Medicine (Dr. Stables); formerly Registrar in Medicine, presently US Public Health Service International Postdoctoral Fellow, Department of Medicine, University of Illinois College of Medicine, 840 S Wood St, Chicago 12 (Dr. Levin).

Departments of medicine and pathology, University of the Witwatersrand and Johannesburg General Hospital.

Footnotes
Received for publication June 24, 1963; accepted June 27.

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