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MELVIN RUBENSTEIN, MD; SHELDON M. WOLFF, MD

Arch Intern Med. 1964;113(3):409-411.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Familial Mediterranean fever (FMF) is a disease characterized by recurrent episodes of fever, peritonitis, or pleuritis,¹ which is probably inherited as an autosomal recessive disorder.² Most of the patients reported with FMF have been of Armenian ³ or Sephardic Jewish ancestry.¹ Although the etiology of FMF is unknown, it has been suggested it may be an "inborn error of metabolism" ⁴ or probably a manifestation of a hypersensitive state.⁵

It was recently reported that some FMF patients excreted increased amounts of urinary histidine as measured by two-dimensional paper chromatography.^4,6,7 On the basis of these reports, aminoaciduria has been suggested as a differential diagnostic criterion for FMF.⁸ We have studied the amino acid excretion with ion-exchange chromatography in five FMF patients both while they were afebrile and pain free and also during spontaneous episodes of fever and peritonitis. The results of these studies demonstrate . . . [Full Text PDF of this Article]

Author Affiliations
BETHESDA, MD

Clinical Associate (Dr. Rubenstein) and Senior Investigator (Dr. Wolff).

Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health.

Footnotes
Received for publication Oct 8, 1963; accepted Oct 28.

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