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ROBERT C. GALLO, MD; WILLIAM FRAIMOW, MD; RICHARD T. CATHCART, MD; ALLAN J. ERSLEV

Arch Intern Med. 1964;113(4):559-568.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Interest in the erythropoietic response in patients with chronic lung disease stems from the fact that, despite arterial hypoxia, the hemoglobin concentration is usually normal.^1-6 Hypoxia under almost all other conditions is associated with a secondary polycythemia. In natives of the Peruvian Andes, Hurtado and co-workers clearly demonstrated that prolonged exposure to high altitudes will produce an increase in hemoglobin and hematocrit proportional to the degree of hypoxia.⁷ Similarly, it has been observed that patients with arterial hypoxemia due to cyanotic heart disease^8,9 and occasionally due to chronic pulmonary disease have secondary polycythemia.

The apparent lack of erythropoietic response in most patients with chronic pulmonary disease has not been explained adequately. Recently it has been emphasized that, if total red cell volume is measured rather than peripheral hemoglobin and hematocrit, patients with chronic pulmonary disease will demonstrate an adequate erythropoietic response.¹⁰ However, the reported data . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO; PHILADELPHIA

Intern in Medicine, The University of Chicago (Dr. Gallo); Associate in Medicine, Jefferson Medical College (Dr. Fraimow); Associate Professor of Medicine, Director, Barton Memorial Division for Diseases of the Chest, in the Department of Medicine, Jefferson Medical College (Dr. Cathcart); Associate Professor of Medicine, Director, Cardeza Foundation for Hematologic Research, in the Department of Medicine, Jefferson Medical College (Dr. Erslev).; From the Charlotte Drake Cardeza Foundation for Hematologic Research, and the Barton Memorial Division for Diseases of the Chest, Jefferson Medical College.

Footnotes
Received for publication Oct 4, 1963; accepted Nov 27.

This paper was read in part before the American Society of Hematology Fifth Annual Meeting, Columbus, Ohio, November, 1962.

Supported by a grant from the United States Public Health Service.

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