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A Case Report

WILLIAM D. DEEP, MD; JOSEPH F. FRAUMENI, MD; CHARLES K. TASHIMA, MD; ROBERT McDIVITT, MD

Arch Intern Med. 1964;113(5):635-640.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The association of a leukoencephalitis with malignant lymphoma and chronic lymphatic leukemia was first reported by Astrom et al¹ in 1958 and was named "progressive multifocal leukoencephalopathy." By 1961, a total of 11 cases of leukoencephalopathy had been reported.² The conditions associated with this demyelinating syndrome were Hodgkin's disease (four cases), chronic lymphatic leukemia (three cases), lymphosarcoma (one case), sarcoidosis (one case), pulmonary and renal tuberculosis (one case), and in one case no systemic illness was mentioned.² Richardson,³ in 1961, reported on 22 cases of progressive multi focal leukoencephalopathy, 20 of which were associated with malignant or granulomatous diseases. Of the remaining two cases, one was associated with coronary artery disease, the other having no known preceding disease. Wiener, Koeze, and Klingon ⁴ have also noted a demyelinating disease in two patients with Hodgkin's disease.

The association of dermatomyositis with neoplastic diseases is also a well-known . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Medical Service, Memorial Hospital for Cancer and Allied Diseases.

Footnotes
Received for publication Sept 10, 1963; accepted Oct 16.

Resident in Medicine, Memorial Hospital (Dr. Deep); formerly Chief Resident in Medicine, Memorial Hospital; present address: National Cancer Institute, Bethesda, Md (Dr. Fraumeni); formerly Fellow in Medicine, Memorial Hospital; present address: Department of Biochemistry, Johns Hopkins University, Baltimore (Dr. Tashima); formerly Resident in Pathology, Memorial Hospital (Dr. McDivitt).

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