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ALAN R. NELSON, MD; GERALD T. PERKOFF, MD; FRANK H. TYLER, MD

Arch Intern Med. 1964;113(5):649-654.

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Introduction

The clinical course of diabetes mellitus may be characterized by extreme lability. In some patients the mechanism responsible for this lability is unknown, but in other cases the "brittle" diabetes is associated with excess insulin administration,^1-4 pregnancy,⁵ or hyperthyroidism.⁶

That pre-existing diabetes mellitus may be made labile by the development of renal glycosuria has not been reported previously. Four such patients are described in this report.

Materials and Methods

Four young diabetic males were found to have renal glycosuria during hospitalization at the University of Utah Affiliated Hospitals from 1957 to 1961 by means of simultaneous blood and urine glucose determinations made on several occasions in each case as follows: The patient was asked to empty the bladder. Thirty minutes later he again voided, and a venous blood sample was obtained. The glucose concentration in the 30-minute urine sample was compared to the glucose level in . . . [Full Text PDF of this Article]

Author Affiliations
SALT LAKE CITY

From the Department of Medicine and the Laboratory for the Study of Hereditary and Metabolic Disorders, University of Utah College of Medicine and the Veterans Administration Hospital.

Footnotes
Received for publication Oct 28, 1963; accepted Nov 7.

A preliminary report of this study was presented at the 22nd Annual Meeting of the American Diabetes Association, Chicago, June 25, 1962.

Diabetes Trainee (Dr. Nelson).

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