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Pubertal HypothyroidismLack of Growth Response After Thyroid Replacement
LCDR FREDERICK L. BENOIT, MC;
LCDR MAYNARD E. JACOBSON, MC
Arch Intern Med. 1964;113(5):665-668.
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Thyroidal failure at puberty produces a syndrome with clinical manifestations intermediate between those of cretinism and adult myxedema. In addition to the symptoms of generalized hypometabolism, there are disturbed gonadal maturation, growth failure, and mental retardation, in variable degrees, dependent on the time of onset and extent of thyroprivia. Although it is stated broadly in textbooks that thyroid hormone replacement will reverse all of the hypothyroid changes, there are few reports which document the effect of therapy on growth. The observation of a patient with pubertal hypothyroidism, growth failure, and nonunited epiphyses, and who had no linear growth but epiphyseal fusion after prolonged thyroid medication, prompts this report.
Report of a Case
This patient, a 22-year-old white man, was admitted to US Naval Hospital, Oakland, Calif, on Jan 22, 1961, following a hypotensive episode. On the day of admission he experienced nausea, vomiting, and periumbilical pain followed by postural syncope.
. . . [Full Text PDF of this Article]
Author Affiliations
USN; USNR
From the Medical Service, US Naval Hospital, Oakland, Calif.
Footnotes
Received for publication Sept 28, 1963; accepted Nov 7.
Present address (Dr. Jacobson): Department of Medicine, University of Minnesota Medical School, Minneapolis.
The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or as reflecting the views of the Medical Department of the Navy or of the Naval Service at large.
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