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HELEN I. GLUECK, MD; LOUIS G. HERRMANN, MD

Arch Intern Med. 1964;113(5):748-757.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The appearance of cold-precipitable fibrinogen (cryofibrinogen, CF) was first reported by Korst and Kratochvil¹ in migratory thrombophlebitis associated with carcinoma. Campbell and co-workers ² studied a patient with purpura and occlusive vascular disease in whose plasma large amounts of the protein were detected.

Kalbfleisch and Bird³ demonstrated similar findings in the plasma of patients with prostatic carcinoma and with pulmonary fibrosarcoma. In subsequent studies McKee and his associates ⁴ detected sizable amounts of the precipitate in the blood of 28 of 650 hospitalized patients. The protein was found to be most frequently associated with metastatic carcinoma, but was also observed in patients with emboli and in collagen disease. Jager ⁵ made similar observations in a patient with leukemia, in two patients with pneumonia, and in one with scleroderma.

Our interest in this subject was aroused by the finding of a large quantity of cryofibrinogen in the plasma of . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI

Footnotes
Received for publication Oct 3, 1963; accepted Dec 2.

Presented in part at the Wayne State University Seminar on Blood Coagulation, Detroit, January, 1957.

Associate Professor of Medicine (Dr. Glueck); Associate Professor of Surgery (Dr. Herrmann). From the departments of medicine and surgery, University of Cincinnati College of Medicine, and the Coagulation Laboratory, Cincinnati General Hospital.

Supported by grants 2904C5 and H6307, Department of Health, Education, and Welfare, US Public Health Service (Dr. Glueck).

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