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SYDNEY LEVINE, MD; MARTIN A. SHEARN, MD

Arch Intern Med. 1964;113(6):826-836.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1924 Eli Moschcowitz ⁸⁹ described an acute, febrile, rapidly fatal illness characterized by hyaline thrombi in the terminal arterioles—a syndrome later termed thrombotic thrombocytopenic purpura (TTP).¹²¹ Subsequently several investigators noted that TTP was occasionally associated with systemic lupus erythematosus (SLE)^12,52,119; however, most authors have denied the existence of any clinical or pathologic relationship between these entities.^{5,8,41,45,54,79,121,136}

Changes compatible with SLE were found at autopsy in two of three patients who died recently of TTP in this hospital. The two cases with features of both conditions are herein reported in detail. In view of the absence in the literature of any study establishing the frequency of this association, published reports of TTP were analyzed for evidence of SLE. Included in the analysis were only those published cases of TTP in which the characteristic pathologic features described by Moschcowitz ⁸⁹ were found at necropsy. In 23% of the . . . [Full Text PDF of this Article]

Author Affiliations
OAKLAND, CALIF

From the Department of Medicine, Permanente Medical Group and Kaiser Foundation Hospital, Oakland, and the Department of Medicine, Rheumatic Disease Group, University of California School of Medicine, San Francisco.

Footnotes
Received for publication Aug 27, 1963; accepted Nov 25.

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