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A Study of Two Siblings

STEPHEN PODOLSKY, MD; AUBREY POTHIER, JR., MD; LEO P. KRALL, MD

Arch Intern Med. 1964;114(4):533-537.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Progressive hereditary cerebellar dysfunction with hypoactive knee and ankle jerks and with onset in preadolescence was first described by Nikolaus Friedreich of Heidelberg in 1863.¹ This disorder is uncommon and constitutes less than 0.5% of total admissions to the National Hospital of London.² The association of Friedreich's ataxia and diabetes mellitus is rare, and its occurrence in two sisters prompts this report.

Report of Cases

CASE 1.

—An 18-year-old girl was first seen in the New England Deaconess Hospital on Oct 19, 1963, with a history of polyuria, intense thirst, and malaise of two months' duration. Glycosuria had been found on a routine test by her mother; there had been no urine tests for the two previous years. The patient was known to have had ataxia since age 5.

Prenatal course and delivery were reported to have been normal. The child sat up at 6 months and walked . . . [Full Text PDF of this Article]

Author Affiliations

From the Joslin Clinic and the New England Deaconess Hospital.

Footnotes

Trainee under National Institutes of Health grant, Joslin Clinic (Dr. Podolsky); Senior Assistant Resident in Internal Medicine, New England Deaconess Hospital (Dr. Pothier); Senior Staff, Joslin Clinic (Dr. Krall).

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