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Meningitis in Adults Caused by Escherichia coli 04 and 075
CALVIN M. KUNIN, MD;
ARTHUR S. BENDER, MD;
CATHERINE M. RUSSELL, PhD
Arch Intern Med. 1965;115(6):652-658.
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ESCHERICHIA COLI rarely produces purulent meningitis in man. Most cares reported in the literature are associated either with overwhelming E coli infections in infants and young children, or with congenital defects in the structures surrounding the spinal cord.1-7 In adults this infection is usually secondary to trauma to the central nervous system (CNS).8-10 Accordingly, the observation of two cases of E coli meningitis, one in a diabetic woman occurring in the setting of diarrhea and a urinary-tract infection, and the other in a woman with an asymptomatic urinary-tract infection, offered the opportunity to assess the possible responsible factors, and to review current concepts of the pathogenesis of E coli infections. Particular attention will be given to serogrouping of E coli, so-called pathogenic E coli, antibody response to infection, and the role of serum complement and diabetes. A review of the experience with E coli meningitis at the University
. . . [Full Text PDF of this Article]
Author Affiliations
CHARLOTTESVILLE, VA
From the departments of preventive medicine, medicine, and microbiology, University of Virginia, School of Medicine. Associate Professor of Preventive Medicine and Medicine (Dr. Kunin); Assistant Resident in Medicine (Dr. Bender); Associate Professor of Microbiology (Dr. Russell).
Footnotes
Received for publication Dec 23, 1964; accepted Dec 29.
Reprint requests to School of Medicine, University of Virginia, Charlottesville, Va (Dr. Kunin).
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