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Clinical Family Studies

ARCHIE A. MacKINNEY, JR., MD

Arch Intern Med. 1965;116(2):257-265.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A LARGE family study of hereditary spherocytosis (HS) has not been reported since Race's classic work in 1942.¹ Since then new hematologic methods, including Coombs' test, the radioactive chromium (⁵¹Cr) erythrocyte survival test, the mechanical fragility test, and autohemolysis have become widely used. Race's report lacked a description of laboratory procedures and data. Young and co-workers ² have reported genetic findings and pedigrees of 28 patients. We have extended their findings by establishing a method of diagnosis of hereditary spherocytosis by statistical analysis of laboratory data.³ These data provided material for genetic analysis by Morton and associates.⁴ The present report contains the clinical findings and pedigrees derived from the laboratory investigation and genetic studies. Of 26 families, 180 members are included.

The criteria for the diagnosis of hereditary spherocytosis were established as follows: four to 13 blood tests (hemoglobin level, erythrocyte indices, fragility indices, reticulocyte count, total serum bilirubin, and . . . [Full Text PDF of this Article]

Author Affiliations
MADISON, WIS

From the Veterans Administration Hospital and the Department of Medicine, University of Wisconsin Medical School. Assistant Professor of Medicine.

Footnotes
Received for publication Sept 11, 1964; accepted Jan 11, 1965.

Reprint requests to 2500 Overlook Terrace, Madison 5, Wisconsin.

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