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Accompanied by Disorders of Blood Coagulation and Pathologic Immune Phenomena

KAZIMIERZ WYSOCKI, MD; STEFAN MACKIEWICZ, MD

Arch Intern Med. 1965;116(3):351-356.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

GAMMA globulins obtained from normal persons and from patients with multiple myeloma have been well characterized. Their immunochemical differences are clearly recognized. Immunoelectrophoretic studies led to the division of these proteins into three basic groups: 6.6S, 7S globulin, β_2A and β_2M-globulin.^1-5 Immune globulins are formed almost entirely in normal plasma cells and their precursors, or result from the metabolism of malignant plasma cells. High levels of individual immune globulins, or structurally abnormal globulins, are usually associated with malignant but immunologically competent cells.

According to Waldenström, however, hypergammaglobulinemia may occur in benign conditions, or as a familial disease. Pathological abnormalities in lymph nodes may be absent.

Changes in immune globulins may be associated with various pathological phenomena; the best known are the altered immune response and hemorrhagic disorders.⁶ The abnormalities usually result from an anomaly in β_2M or _7S-globulin; they are less common as a result of β_2M . . . [Full Text PDF of this Article]

Author Affiliations
POZNAN, POLAND

From the Third Department of Internal Medicine, Academy of Medicine. Professor of Medicine, Head (Dr. Wysocki); Associate Professor of Medicine (Dr. Mackiewicz).

Footnotes
Received for publication July 23, 1964; accepted Jan 4, 1965.

Reprint requests to Third Department of Internal Medicine, Academy of Medicine, Poznan, Poland (Dr. Wysocki).

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