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I. ARNOLD SLOWE, MD; ANNE C. CARTER, MD; ELAINE B. FELDMAN, MD

Arch Intern Med. 1965;116(4):523-530.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THORP AND WARING demonstrated that clofibrate (Atromid S) lowered levels of serum and liver cholesterol in rats.¹ Other studies suggested that a mixture of androsterone and clofibrate (Atromid) potentiated the lipid-lowering effect.² The successful use of this mixture to decrease serum lipid concentration in patients with coronary sclerosis by Oliver in 1962³ prompted the present study of the effects of clofibrate alone or with androsterone in patients with frank disorders of lipid metabolism. In the course of these investigations, published reports suggested that clofibrate alone was responsible for the lipid-lowering action of the mixture and that addition of androsterone produced no enhancement.^4-8

Materials and Methods

The patients (Table 1) ranged in age from 10 to 72 years. They included four men, three women with hyperlipemia, a boy with idiopathic hyperlipemia, and a boy with glycogen-storage disease (glucose-6-phosphatase deficient). In five of seven families studied familial incidence of hyperlipemia was demonstrated. . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN

From the Department of Medicine, State University of New York Downstate Medical Center and the Kings County Hospital, Brooklyn. Instructor, Department of Medicine (Dr. Slowe); Associate Professor, Department of Medicine (Dr. Carter); and Assistant Professor, Department of Medicine (Dr. Feldman).

Footnotes
Received for publication Sept 30, 1964; accepted March 24, 1965.

A preliminary report of these data was read before the New York regional meeting of the American College of Physicians, Jan 14, 1964.

Reprint requests to State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 (Dr. Carter).

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