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Clinical and Laboratory Findings

GILBERT M. SCHIFF, MD; JOHN L. SEVER, MD, PhD; ROBERT J. HUEBNER, MD

Arch Intern Med. 1965;116(4):537-543.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SINCE the initial observations of Gregg,¹ the adverse effects resulting from maternal rubella infection during the early part of pregnancy have been well recognized. Although rubella has been assumed to be of viral etiology, it was not until recently that the isolation of the virus in tissue culture and the detection of neutralizing antibody in patients was described.^2-4 With the availability of these methods, it has become possible to conduct detailed studies correlating the laboratory findings with the clinical course of experimentally produced disease. Studies of this type can provide a better understanding of the disease, and hence a more intelligent approach to the prophylaxis, and perhaps eventually the control of the disease. The present investigation describes the clinical and laboratory findings for young adults following experimental intranasal infection with tissue culture grown rubella virus.

Materials and Methods

This investigation was undertaken as part of three volunteer studies . . . [Full Text PDF of this Article]

Author Affiliations
BETHESDA, MD

From the National Institutes of Health, Bethesda, Md. Head, Unit on Tissue Culture Investigations, Section on Infectious Diseases, Perinatal Research Branch, National Institute of Neurological Diseases and Blindness and presently Assistant Professor of Medicine and Microbiology, College of Medicine, University of Cincinnati, Cincinnati (Dr. Schiff); Head, Section on Infectious Diseases, Perinatal Research Branch, National Institute of Neurological Diseases and Blindness (Dr. Sever); Chief, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (Dr. Huebner).

Footnotes
Received for publication Jan 21, 1965; accepted March 15.

Read in part before the Midwest Section, American Federation for Clinical Research, Oct 30, 1963, Chicago.

Reprint requests to Department of Medicine. Cincinnati General Hospital, Cincinnati, Ohio 45229 (Dr. Schiff).

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