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E. BERRY HEY, JR., MD; NORMAN MAKOUS, MD; JOSEPH B. VANDER VEER, MD

Arch Intern Med. 1965;116(4):544-547.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Chills and fever are considered to be rare toxic reactions to procainamide hydrochloride therapy. There are only five ^1-7 documented case reports of such reactions in the literature. We have recently encountered this reaction in three patients within a five-week period and it would seem that these complications may not be as rare as the literature implies. They may present a considerable problem in differential diagnosis, as is illustrated by the following cases histories.

Report of Cases

CASE 1.

—A 35-year-old white woman was readmitted to the Pennsylvania Hospital on April 30, 1964. In March of 1964 she had been hospitalized for a period of four weeks with severe congestive heart failure secondary to rheumatic heart disease. Mitral stenosis, aortic stenosis, and atrial fibrillation were present. During this first admission the patient responded to digitalis and diuretics. An attempt to convert the atrial fibrillation to normal sinus rhythm with quinidine . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Cardiovascular Department, Pennsylvania Hospital (formerly Resident in Cardiology: Dr. Hey), and the School of Medicine, University of Pennsylvania (Associate in Medicine: Dr. Makous; Associate Professor of Clinical Medicine: Dr. Vander Veer).

Footnotes
Received for publication Jan 19, 1965; accepted Feb 5.

Reprint requests to 330 S 9th St, Philadelphia 19107 (Dr. Vander Veer).

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