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DAVID RIFKIND, PhD, MD

Arch Intern Med. 1965;116(4):554-558.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CHARACTERISTIC basophilic intranuclear inclusion body-containing cells morphologically compatible with viral infection were observed in autopsy lung specimens from 15 of 32 patients treated at this center by means of organ transplantation.¹ These inclusions have been demonstrated in the brains of two patients and in an additional ten cases other histologic evidence of viral CNS infection was present.² In three patients the inclusion body-containing cells were also disseminated to the lymph nodes, liver, pancreas, parathyroid, and salivary glands.¹ In addition, a segment of donor ureter resected 228 days posttransplant because of stricture also contained these inclusions.³

It is the purpose of this communication to report the isolation and identification of a viral agent from the lungs of three patients who died following renal homotransplantation.

Methods

Tissue Culture.

—Specimens of lung obtained at autopsy were ground to approximately a 10% suspension in tissue culture medium. This consisted of Eagle's minimal essential medium . . . [Full Text PDF of this Article]

Author Affiliations
DENVER

From the Department of Medicine, University of Colorado School of Medicine. Assistant Professor.

Footnotes
Received for publication Feb 11, 1965; accepted March 4.

Read before the Western Section of the American Federation for Clinical Research, Carmel, Calif, Jan 28-30, 1965.

Reprint requests to University of Colorado Medical Center, 4200 E 9th Ave, Denver, Colo 80220.

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