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BYONG S. MIN, MD; V. WILLIAM COLE, MD

Arch Intern Med. 1965;116(4):581-585.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

BECAUSE of the recent innovation of the metyrapone test as a measure of endogenous ACTH reserve,^1,2 methodological variations on this technique have not been clarified. The dosage, route, and time of day the drug is administered are as important to the final result of the test as is the selection of the appropriate steroid analytical procedures.³ The paucity of reports concerning use of the intravenous route of administration and the current controversy over the results even in normal individuals ⁴ prompt us to report our experience.

This study documents the findings in control subjects and in patients with chromophobe adenoma of the pituitary gland. Increments in the total urinary Porter-Silber chromogens which occurred after the administration of intravenous metyrapone were employed as an indirect measure of pituitary adrenocorticotrophic hormone (ACTH) reserve.

Materials and Methods

Thirteen control subjects and eighteen patients with chromophobe adenoma seen at The University . . . [Full Text PDF of this Article]

Author Affiliations
HOUSTON

From the University of Texas M. D. Anderson Hospital and Tumor Institute. Associate Internist Department of Medicine (Dr. Cole). Clinical fellow, American Cancer Society, 1963-1964, and presently at Catholic Medical College, St. Mary's Hospital, Seoul, Korea (Dr. Min).

Footnotes
Received for publication Sept 29, 1964; accepted March 29, 1965.

Reprint requests to University of Texas M. D. Anderson Hospital and Tumor Institute, Bertner Dr, Houston, Tex 77025 (Dr. Cole).

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