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ALFRED EICHENHOLZ, MD

Arch Intern Med. 1965;116(5):699-708.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

A PRIMARY reduction in the physically dissolved fraction of carbon dioxide in blood defines the state of primary respiratory alkalosis (primary hypocapnia). The quantity of physically dissolved CO₂ ([H₂CO₃]) in blood depends on the partial pressure of CO₂ (P_co2).¹

Arterial blood P_co2, is in equilibrium with pulmonary alveolar air P_co2, which in turn is directly proportional to alveolar air CO₂ concentration (F CO₂).

Increase in alveolar ventilation, which defines the state of hyperventilation, results in reduction of alveolar F CO₂ and therefore reduction in alveolar and arterial P_co2. A schematic demonstration of F CO₂-P_co2 relationship is seen in Fig 1. Thus, primary hyperventilation results in a reduction in alveolar P_co2 and consequential reduction in arterial P_co2-the state of respiratory alkalosis.

Hyperventilation.

—The term "hyperventilation" should not be used to describe an accelerated rate of respiration (tachypnea), since such does not necessarily result in an increase in alveolar ventilation. Furthermore, . . . [Full Text PDF of this Article]

Author Affiliations
MINNEAPOLIS

Chief, Clinical Radioisotope Section, Minneapolis Veterans Hospital and Assistant Professor of Medicine, University of Minnesota.

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