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Treatment With Vinblastine A COOPERATIVE STUDY

Arch Intern Med. 1965;116(6):846-852.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ONE OF THE most important advances in clinical cancer chemotherapy in recent years has been the demonstration that products of the periwinkle plant Vinca rosea Linn. have antitumor activity in patients with neoplastic disease.¹ Vinblastine has been effective in patients with Hodgkin's disease and lymphosarcoma.^2,3 There is also evidence for some degree of antitumor activity in a variety of solid tumors, particularly carcinoma of the breast, but the extent of this effect is not clear.¹ The Eastern Cooperative Group in Solid Tumor Chemotherapy undertook preliminary studies of vinblastine in 1961. Dose response studies indicated that for the majority of patients 0.3 mg/kg was well tolerated, producing in most of the patients mild to moderate, reversible myelosuppression.³ Because occasionally a patient had myelosuppression with smaller doses, it was proposed that the doses employed in the therapeutic trial start at 0.1 mg/kg/week and be increased by 0.1 mg/kg/week to a maximum of . . . [Full Text PDF of this Article]

Footnotes
Received for publication May 17, 1965; accepted June 23.

This study was undertaken by the Eastern Cooperative Group in Solid Tumor Chemotherapy (Chairman, Bruce I. Shnider, MD) and the Acute Leukemia Cooperative Group B (Chairman, James F. Holland, MD) under the auspices of the Collaborative Clinical Trials Program of the National Cancer Institute. For a complete listing of participants see the footnote at the end of the communication.

Reprint requests to the University of Texas, M.D. Anderson Hospital, Houston, Tex 77025 (Dr. Frei).

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