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A Clinicopathologic Study

ALLAN E. GARB, MD; EDWARD H. SOULE, MD; LLOYD G. BARTHOLOMEW, MD; JAMES C. CAIN, MD

Arch Intern Med. 1965;116(6):899-906.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE HE NUMEROUS REPORTS on gastric ulcer associated with adrenal steroid therapy show little agreement on pathogenesis, clinical characteristics, frequency of occurrence, radiologic appearance, duration and amount of steroid therapy necessary to induce pathologic change, and the appropriate treatment of such ulcers.

There have been inadequate control studies correlating clinical, gross, and microscopic findings in steroid-induced gastric ulcer in man. Several investigators ^1-3 have noted pathologic differences in isolated cases or in small series.

The present study was undertaken to determine whether the clinical course and pathology of the gastric ulcer developing during the administration of adrenal steroids differ from those of other gastric ulcers.

As used herein, the term "steroid" shall mean adrenal corticosteroid and the term "steroid ulcer" shall mean a gastric ulcer developing in association with adrenocorticosteroid therapy.

Selection of Patients

The records of 1,084 patients who underwent gastric resection for one or more gastric ulcers at . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN

From the Mayo Clinic and Mayo Foundation: Section of Surgical Pathology (Dr. Soule) and of Medicine (Drs. Bartholomew and Cain). Mayo Graduate School of Medicine (University of Minnesota), Rochester: Resident in Medicine (Dr. Garb).

Footnotes
Received for publication April 28, 1965; accepted Aug 17.

Reprint requests to the Section of Publications, Mayo Clinic, Rochester, Minn 55901.

This investigation was supported in part by Research grant AM-06908 from the National Institutes of Health, US Public Health Service.

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