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PHIN COHEN, MD; FRANK H. GARDNER, MD

Arch Intern Med. 1966;117(1):113-124.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE PURPOSE of this report is to present data on six cases of infection with gram-negative bacteria in which platelet counts and white blood cell and differential counts of peripheral blood were followed frequently throughout the hospital course and afterwards when possible. These data suggest that thrombocytopenia has not received sufficient emphasis as a sign and possible complication of infection with gram-negative bacteria.^1,2

Not only was thrombocytopenia a good index of continuing sepsis in these cases, but it also often persisted after an initial granulocytopenic phase had progressed to granulocytosis, sometimes of marked degree. Thus, in our experience, divergence of the granulocyte and platelet count has sometimes suggested gram-negative bacteremic infection. In one case, ⁵¹Cr platelet lifespan studies were done during uncontrolled sepsis as well as during the recovery phase. These studies suggested that peripheral platelet destruction may account for the observed thrombocytopenia.

Materials and Methods

The . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Richard C. Curtis Hematology Laboratory, Peter Bent Brigham Hospital, and the Department of Medicine, Harvard Medical School.

Footnotes
Received for publication Aug 15, 1965; accepted Sept 8.

Reprint requests to Peter Bent Brigham Hospital, 721 Huntington Ave, Boston, Mass 02115 (Dr. Cohen).

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