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Report of One Case of Leukemia and Two Cases of Down's Syndrome

PATRICK E. CONEN, MB, BS, MRCP; BAYZAR ERKMAN, MD; BERNARD LASKI, MD, FRCP

Arch Intern Med. 1966;117(1):125-132.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The.HE FREQUENT association of mongolism (Down's syndrome) and leukemia^1,2 suggests a close relationship between the two conditions, particularly when figures are corrected for the high infant mongol mortality from infection and heart disease. This relationship is also demonstrated by reports of cases of mongolism and leukemia in the same family.^3-6 It is of interest that chromosome abnormalities occur in both conditions. These abnormalities have been regularly found in mongolism,⁷ chronic granulocytic leukemia,⁸ and acute leukemias.^9,10

This report describes a family with two mongols and a leukemic child in the same sibship. The role of radiation in leukemia and chromosomal trisomy is discussed because the mother was a radiographer for 5 years with a risk of occupational radiation exposure.

Report of Cases

The family was first encountered when the eldest child was referred for chromosome investigation of leukemia. The three children were aged 7 years, 4 years, and 2 months, respectively, . . . [Full Text PDF of this Article]

Author Affiliations
TORONTO

From the departments of pathology and pediatrics and the Research Institute, the Hospital for Sick Children, and the University of Toronto.

Footnotes
Received for publication June 21, 1965; accepted Sept 7.

Reprint requests to 555 University Ave, Toronto 2, Canada (Dr. Conen).

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