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ZACHARY M. KILPATRICK, MC

Arch Intern Med. 1966;117(1):47-53.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HEPATIC functional impairment in infectious mononucleosis is nearly universal^1,2 and histologic changes in the liver are regularly encountered.^3-6 To this time, no study correlating the extent of altered structure and functional abnormalities has appeared. This study presents such a correlation and describes the findings which suggest that the degree of abnormality in certain liver-function tests in infectious mononucleosis is well correlated with the extent of accumulation of mononuclear round cells in the lobular sinusoids.

Materials and Methods

Twenty military patients were admitted to the hospital with the diagnosis of infectious mononucleosis between September 1962 and April 1963. Each had the characteristic clinical picture, atypical lymphocytes in the peripheral blood and diagnostic heterophil titers and adsorption studies.⁷ Liver-function studies were performed in each case and were repeated at weekly intervals. These included total and one-minute bilirubin, serum alkaline phosphatase (SAP),⁸ serum glutamic pyruvic transaminase (SGPT),⁹sulfobromophthalein retention (BSP),¹⁰ cephalin cholesterol flocculation, . . . [Full Text PDF of this Article]

Author Affiliations
USA

From the Medical Service, Fifth General Hospital, Bad Caunstatt, Germany.

Footnotes
Received for publication June 21, 1965; accepted July 12.

Read before the US Army Medical-Surgical Training Conference, Garmisch, Germany, May 23, 1963.

Reprint requests to 333 Cedar St, New Haven, Conn 06510.

This material has been reviewed by the Office of the Surgeon General, Department of the Army, and there is no objection to its presentation or publication, or both. This review does not imply any indorsement of the opinions advanced or any recommendation of such products as may be named.

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