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Thiamine Depletion as Measured by Erythrocyte Transketolase Changes

EXPEDITO N. HARO, MD; MYRON BRIN, PhD; WILLIAM W. FALOON, MD

Arch Intern Med. 1966;117(2):175-181.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE INCREASING use of total fasting as an effective method of producing weight loss in the very obese has led to a review of the status of vitamin nutrition in such individuals. Although it has been suggested by some authors ^1,2 that vitamin deficiency does not occur during a total fast and others ^3,4 have recommended the routine use of vitamin supplements, no supporting data have been offered. Such data as are available were obtained during semistarvation regimens,^5-7 were usually secured during observations of normal nonobese humans and were based upon urinary vitamin excretion. Since, in current use, fasting as a therapeutic procedure ordinarily involves no caloric intake for periods of a week or more in markedly overweight patients, we have undertaken this study of thiamine changes in patients so treated using erythrocyte transketolase activity as an improved technique for functional evaluation of thiamine metabolism. The observations indicate . . . [Full Text PDF of this Article]

Author Affiliations
SYRACUSE, NY

From the departments of medicine and biochemistry, Upstate Medical Center, State University of New York and University Hospital, Syracuse.

Footnotes
Received for publication Sept 1, 1965; accepted Sept 13.

Read in part before the annual meeting of the American Society for Clinical Nutrition, May 2, 1964.

Reprint requests to University Hospital, Syracuse, NY 13210 (Dr. Faloon).

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