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Effects of Large Doses of Phytonadione

HAROLD S. BALLARD, MD; AARON J. MARCUS, MD

Arch Intern Med. 1966;117(2):182-186.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT HAS BEEN suggested that administration of large doses of vitamin K or its analogues over a prolonged period to adults with severe liver disease can be hazardous. Cases have been cited in which a normal Quick one-stage prothrombin time became abnormal, or a preexisting abnormality of the prothrombin time was increased if the patient receiving vitamin K or its analogues had chronic liver disease.^1-8 In several instances ^1-7 a hemorrhagic diathesis associated with profound hypoprothrombinemia was described. In one of these the bleeding was stated to be accompanied by significant alterations in liver function tests, and these complications were attributed to toxic properties of vitamin K.⁷

On the other hand, administration of large doses of vitamin K to patients with mild or moderate liver disease resulted in improvement of the Quick one-stage prothrombin time.^1,3-5,8-10 Taine and Juvanon 11 reported favorable responses to vitamin K even in . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Hematology Section, New York Veterans Administration Hospital and the Department of Medicine, Cornell University Medical College.

Footnotes
Received for publication July 26, 1965; accepted Oct 18.

Reprint requests to New York Veterans Administration Hospital, 408 First Ave, New York, NY 10010 (Dr. Ballard).

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