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Study of Two Large Midwestern Kindreds

H. T. LYNCH, MD; M. W. SHAW, MD; C. W. MAGNUSON, MD; A. L. LARSEN, MD; A. J. KRUSH, MS

Arch Intern Med. 1966;117(2):206-212.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

MENDELIAN autosomal inheritance patterns have been demonstrated in familial aggregations of polyposis coli, retinoblastoma, xeroderma pigmentosum, neurofibromatosis,¹ Gardner's syndrome² and the basal cell nevus syndrome.³ In addition, an increased familial incidence of carcinoma of the breast,⁴ lung,⁵ stomach and colon,⁶ and prostate,⁷ as well as leukemia,⁸ multiple myeloma,⁹ Waldenström's macroglobulinemia,¹⁰ pheochromocytoma,¹¹ multiple endocrine tumors,¹² cerebellar hemangioblastoma,¹³ and malignant melanoma ¹⁴ has been observed. However, the mode of inheritance is not clear in these latter conditions. In appraising these data, it must be kept in mind that only those families showing a high incidence of carcinoma are "selected" for publication. When one considers the high population incidence of carcinoma, "... it is bound to occur in excess in some families according to the operation of the laws of probability.¹⁵ "

The purpose of this paper is to present the findings in two large midwestern kindreds in which a high frequency of . . . [Full Text PDF of this Article]

Author Affiliations
OMAHA; ANN ARBOR, MICH; OMAHA

From the departments of internal medicine and pathology and the Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska College of Medicine, Veterans Administration Hospital, Omaha, and the Department of Human Genetics, University of Michigan Medical School, Ann Arbor.

Footnotes
Received for publication Aug 6, 1965; accepted Oct 1.

Read in part before the American Society of Human Genetics, Boulder Colo, August 1964.

Reprint requests to Eppley Institute, 42nd & Dewey Ave, Omaha, Neb 68105 (Dr. Lynch).

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