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Sodium Ampicillin Given Parenterally
MARVIN TURCK, MD;
RONALD H. SMITH, MD;
JAMES F. WALLACE, MD;
ROBERT G. PETERSDORF, MD
Arch Intern Med. 1966;117(2):242-249.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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AMPICILLIN, is a semisynthetic penicillin which is effective against penicillinsusceptible gram-positive organisms as well as many prevalent gram-negative pathogens.1-7 The oral preparation in clinical use which consists of the free acid of ampicillin has been under extensive trial since 1961 and was made available commercially in the United States in 1964. Several studies have indicated that it is fairly stable in the presence of gastric acid, and is absorbed readily from the gastrointestinal tract; is not bound to protein in appreciable quantity; is distributed well into most tissues; and generally is well tolerated and safe.8-10 Less is known regarding the sodium salt of ampicillin which recently has been made available for parenteral administration.11-14 This report describes the use of the sodium salt of ampicillin in the treatment of 124 hospitalized patients with a variety of systemic infections.
Materials and Methods
Selection of Patients.
—Patients admitted to the General Medical and
. . . [Full Text PDF of this Article]
Author Affiliations
SEATTLE
From the Department of Medicine, University of Washington School of Medicine, and King County Hospital, Seattle.
Footnotes
Received for publication July 21, 1965; accepted Sept 20.
Read in part before the Fourth Interscience Conference on Antimicrobial Agents and Chemotherapy, New York 1964.
Reprint requests to King County Hospital, Seattle, Wash 98104 (Dr. Turck).
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