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LEON GOLDMAN, MD; GILBERT S. GORDAN, PhD, MD

Arch Intern Med. 1966;117(3):383-388.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE PRESENT state of our knowledge concerning the physiology of the parathyroid glands has developed by observing the effects of parathyroidectomy,^1,2 noting the responses following parathyroid extract administration,^3,4 by studies of the metabolism of calcium and phosphorus, and systematic observations of parathyroid function in the normal and abnormal state. Excessive parathyroid hormone elevates the serum calcium and has a phosphate diuretic influence.⁴ Recently, Copp et al,⁵ showed that the extract contains a fraction which lowers previously elevated serum calcium. Whether this originates from thyroid or parathyroid in man has yet to be determined.

Normal Homeostasis of Calcium and Phosphate

It is generally agreed that the main physiologic actions of the parathyroid glands are upon the metabolism of calcium and phosphate, and therefore upon bone, which is the chief reservoir of these two minerals.

The parathyroid glands provide one of the chief mechanisms for the maintenance of a constant serum calcium . . . [Full Text PDF of this Article]

Author Affiliations
SAN FRANCISCO

From the departments of surgery and medicine, University of California School of Medicine, San Francisco.

Footnotes
Received for publication Oct 13, 1965; accepted Nov 15.

Reprint requests to University of California School of Medicine, San Francisco, Calif 94122 (Dr. Goldman).

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