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A Clue to the Early Diagnosis of Myeloproliferative Disorders

DONATO ALARCON-SEGOVIA, MD; RICHARD R. BABB, MD; JOHN F. FAIRBAIRN II, MD; ALBERT B. HAGEDORN, MD

Arch Intern Med. 1966;117(4):511-515.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ERYTHERMALGIA is a disorder characterized by burning distress of the extremities accompanied by redness and increased temperature of the skin. These symptoms are often initiated by an increase in environmental temperature and relieved by measures that cool the skin.¹ Smith and Allen ² divided erythermalgia into primary and secondary forms depending on whether or not there were associated disease states in the neurologic, vascular, or hematologic systems. In a recent study of 51 cases of erythermalgia seen at the Mayo Clinic in the years 1951 through 1960 we found 21 cases of the secondary form.³ Of particular interest was our finding that in eight patients with a myeloproliferative disease the "secondary" erythermalgia preceded recognition of the hematologic disorder by up to 16 years. We report these cases herein to call attention to this early diagnostic clue.

Material

The myeloproliferative syndrome may be defined as an unexplained, persistent proliferation . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN

From the Mayo Clinic and Mayo Foundation: Section of Medicine (Drs. Fairbairn and Hagedorn). Mayo Graduate School of Medicine, University of Minnesota (Drs. Alarcón-Segovia and Babb).

Footnotes
Received for publication Oct 27, 1965; accepted Jan 28, 1966.

Reprint requests to Section of Publications, Mayo Clinic, Rochester, Minn 55902.

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