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Report of a Case and Inquiry Into Mechanism

HAL B. RICHERSON, MD; PAUL M. SEEBOHM, MD

Arch Intern Med. 1966;117(4):568-572.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

I NTRAMUSCULAR injection of human -globulin (HGG) is regarded as safe as a result of extensive clinical use. In contrast, intravenous administration of commercial human -globulin is considered hazardous.

The term "-globulin" is based on electrophoretic mobility. Recent immunologic techniques have further defined this class of serum proteins, and standard terminology has been proposed.¹ The -globulins comprise a group of at least three immunoglobulins: IgG or G; IgA or A; and IgM or M. Commercial HGG prepared by ethanol fractionation (Cohn fraction II) is homogeneous on electrophoresis and reportedly contains 100% "-globulin" as shown by this technique.² Recently, much attention has been given to the formation of aggregates of HGG by heating.^3,4 There is evidence also that aggregates of HGG form spontaneously and are present in varying amounts in commercial HGG.⁵ Of the three immunoglobulins, only IgG seems to form "biologically active" aggregates as measured by complement fixation.⁶ The . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Allergy Section, Department of Internal Medicine, University of Iowa. Dr. Richerson is an Iowa Thoracic Society Trainee in Pulmonary Disease.

Footnotes
Received for publication Sept 1, 1965; accepted Dec 1.

Read in part before the North Central Allergy Society, Rochester, Minn, May 2, 1965.

Reprint requests to University Hospitals, Iowa City, Iowa 52241 (Dr. Seebohm).

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