This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (116)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Importance of Basal Acid Output

TOSHIO AOYAGI, MD; W. H. J. SUMMERSKILL, DM, MRCP

Arch Intern Med. 1966;117(5):667-672.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

AN INCREASING proportion of patients with peptic ulcer due to gastrin-producing islet cell tumor are being recognized in whom features of the syndrome are atypical or delayed in onset.^1-4 In such instances, identifying the tumor and establishing its causal relationship with the ulcer ^2,4-6 may involve complex surgical and biochemical methods.^7,8 The purpose of this paper is therefore to investigate the diagnostic importance of gastric secretory findings.

Zollinger and Ellison ⁹ originally emphasized abnormally high nocturnal gastric secretion as characteristic of this syndrome, a finding confirmed by others.¹⁰ Summerskill ¹¹ found a greatly increased one-hour basal acid output which approximated unusually the acid response to an augmented dose of histamine. Rawson and co-workers ¹² and Marks and associates ¹³ reported similar results, and Marks and colleagues proposed that the ratio of basal to maximal acid secretion would be useful in diagnosis of the syndrome.¹³ Information included in many subsequent case . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN

From the Mayo Clinic and Mayo Foundation: Gastrointestinal Research Unit (Dr. Summerskill). Mayo Graduate School of Medicine, University of Minnesota, Rochester (Dr. Aoyagi).

Footnotes
Received for publication Sept 1, 1965; accepted Feb 28, 1966.

Reprint requests to Section of Publications, Mayo Clinic, Rochester, Minn 55901.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?