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Analysis of Circadian Rhythms in Human Adrenocortical Secretory Activity
GRANT W. LIDDLE, MD
Arch Intern Med. 1966;117(6):739-743.
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RHYTHMICITY has long been known to be a characteristic of many biological functions, and the mechanisms underlying biological rhythms have been of increasing interest to investigators during recent years. Some biological rhythms have been referred to as "endogenous" (self-sustained) since they are not closely correlated with any obviously rhythmic phenomena in the external environment. Others, which are obviously correlated with cyclic changes in the external environment, have been called "exogenous" (forced). Halberg 1 has used the term "circadian" ("circa"—about, "dies"—day) in referring to biological rhythms having a period of about one day.
Several studies have provided evidence that adrenal steroids are secreted on a cyclic schedule with a period of about 24 hours.2-6 By rescheduling the activities of normal subjects, it has been possible to change the hour at which adrenal steroid production rises and falls.7 All studies prior to the present one, however, have been alike
. . . [Full Text PDF of this Article]
Author Affiliations
NASHVILLE, TENN
From the Department of Medicine, Vanderbilt University School of Medicine, Nashville.
Footnotes
Received for publication Dec 16, 1965; accepted Dec 21.
Presented as the Jeremiah Metzger Lecture at the 78th Annual Meeting of the American Clinical and Climatological Association, Williamsburg, Va, Oct 25-27, 1965.
Reprint requests to Vanderbilt University School of Medicine, Nashville, Tenn 37203 (Dr. Liddle).
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