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DOUGLAS B. McGILL, MD; H. ROYDEN JONES, JR., MD

Arch Intern Med. 1966;117(6):784-788.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

STUDY of the systemic manifestations of malignant tumors has resulted in the delineation of a wide variety of syndromes.¹ In many instances the tumors probably manufacture substances that have endocrine-like activity. Although rather specific syndromes were described initially, further case reports indicate more complex interrelationships among syndromes. The metastatic carcinoid tumor illustrates the diverse biochemical potential of the malignant cell. Biörck and associates² in 1952 first described the clinical picture; Thorson³ in 1958, summarizing the literature to that time, described a rather characteristic syndrome of diarrhea and flushing that was sometimes associated with cardiac lesions and bronchial constriction. Central to this syndrome are hepatic metastases from carcinoid tumors producing high levels of various indoles in the serum and urine.^4,5 Since 1958, many cases have been described that are atypical in respect to clinical symptoms, biochemical findings, and tissue of origin. These tumors are often associated with other "endocrine" tumors.^8,7 The . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN

From the Mayo Clinic and Mayo Foundation: Section of Medicine (Dr. McGill). Mayo Graduate School of Medicine (University of Minnesota), Rochester (Dr. Jones).

Footnotes
Received for publication Sept 29, 1965; accepted March 28, 1966.

Reprint requests to Mayo Clinic, 200 First St SW, Rochester, Minn 55901.

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