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Gastrointestinal Bleeding in von Willebrand's DiseaseCase Report With Discussion of the Diagnostic and Therapeutic Problems Involved
S. BRANDSTAETTER, MD;
J. SCHARF, MD;
H. SALOMON, MD;
I. TATARSKY, MD
Arch Intern Med. 1966;118(2):108-110.
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VON WILLEBRAND first described a constitutional and hereditary hemorrhagic diathesis in 1926. Even though this disorder has retained its initial name, numerous investigations performed since then have modified the original concept of that disorder. It can at present be defined as the association of a prolonged bleeding time with a decrease in factor VIII (antihemophilic factor [AHF] ).1,2 As has been shown by Nilsson, these defects are due to the absence of a plasmatic factor.
Report of a Case
This case report concerns a 23-year-old man known to our hematology laboratory since the age of 10 years. Investigations carried out in the rest of his family showed that no coagulation defect could be detected in the parents and two other siblings, while a younger brother presented the same symptoms. However, the parents were first cousins; and though we failed to detect the defect in any of them and thus to
. . . [Full Text PDF of this Article]
Author Affiliations
HAIFA, ISRAEL
From Medical Department A, Hematological Laboratory, Rambam Government Hospital, Haifa, Israel. The present address of Dr. Brandstaetter is Department of Medicine, University of Washington, Seattle, Wash 98105.
Footnotes
Received for publication April 14, 1966; accepted May 23.
Reprint requests to Rambam Government Hospital, Haifa, Israel (Dr. Brandstaetter).
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