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New Bone Formation in Osteoporosis Following Treatment With Sodium Fluoride
ROGER M. CASS, MD;
JOSEPH D. CROFT, JR., MD;
PETER PERKINS, MD;
WILLIAM NYE, MD;
CHRISTINE WATERHOUSE, MD;
ROGER TERRY, MD
Arch Intern Med. 1966;118(2):111-116.
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O STEOSCLEROSIS associated with chronic fluoride exposure is well documented.1,2 Sodium fluoride has been used experimentally in the treatment of Paget's disease of bone, osteogenesis imperfecta, multiple myeloma, and osteoporosis.3-7 Clinical and metabolic results have been obtained in these patients but detailed microscopic data on the effects of fluoride treatment on the bone have not been reported.
The present report describes a patient with ulcerative colitis and hepatic cholangiolitis who was treated with corticosteroids with subsequent appearance of osteoporosis and vertebral body collapse. Sodium fluoride therapy was instituted for the osteoporosis and because of the active ulcerative colitis and liver disease, the patient was continued on corticosteroids. The present study was undertaken to obtain clinical, metabolic, and histologic data on this patient who was treated simultaneously with sodium fluoride and corticosteroids.
Report of a Case
A 63-year-old, married, white female (SMH 13-15-97) entered the hospital because of diarrhea
. . . [Full Text PDF of this Article]
Author Affiliations
ROCHESTER, NY
From the departments of medicine and pathology, University of Rochester School of Medicine and Dentistry, Rochester.
Footnotes
Received for publication Jan 14, 1966; accepted March 10.
Reprint requests to University of Rochester School of Medicine and Dentistry, Rochester, NY 14620 (Dr. Cass).
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