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WILLIAM J. FLANIGAN, MD; GEORGE L. ACKERMAN, MD

Arch Intern Med. 1966;118(2):117-122.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ETHACRYNIC acid (MK-595), an unsaturated ketone derivative of phenoxyacetic acid, was reported to be an effective diuretic in experimental animals in 1962.^1,2 Subsequent reports ^3-6 have confirmed its diuretic activity in man. The drug has attracted the attention of clinicians because of its potent therapeutic effect in edematous states refractory to conventional diuretic therapy. Studies, during antidiuresis by Goldberg et al⁷ and during water diuresis by Earley and Friedler,⁸ suggested that the drug's primary action in the kidney was inhibition of sodium transport in the ascending limb of Henle's loop. Activity at this site is unique among all other diuretics, with the possible exception of furosemide.⁹ Although the effect of ethacrynic acid on urine concentration and dilution are consistent with a block in sodium reabsorption at this segment of the nephron, both Goldberg and associates and Earley and Friedler indicated that it might have an additional effect at another site. . . . [Full Text PDF of this Article]

Author Affiliations
LITTLE ROCK, ARK

From the Department of Medicine, University of Arkansas Medical Center, Little Rock, Ark.

Footnotes
Received for publication March 31, 1966; accepted May 12.

Reprint requests to Department of Medicine, University of Arkansas Medical Center, Little Rock, Ark (Dr. Flanigan).

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