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JULIAN KATZ, MD

Arch Intern Med. 1966;118(3):265-269.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE PROBLEM of separating adrenocortical hyperplasia, adenoma or carcinoma in the patient with Cushing's syndrome prior to surgery is of considerable importance and has stimulated the development of certain differential laboratory tests. The measurement of urinary hydroxycorticoids is a practical representation of the secretion of cortisol.¹ Liddle ² has shown that in normal individuals the excretion of 17-hydroxycorticoids will be suppressed by small amounts of a potent synthetic steroid, dexamethasone. Cortisol production in the presence of adrenocortical hyperplasia will not be suppressed by the dose of 2 to 3 mg of dexamethasone, but will be reduced to negligible levels by the administration of 8 to 9 mg a day; there will be no suppression in the case of adrenocortical neoplasia. The responsiveness of the adenoma to corticotropin-zinc hydroxide, as measured by cortisol production, is said to distinguish it from a carcinoma,³ but this differentiation has been inconstant. . . . [Full Text PDF of this Article]

Author Affiliations
DURHAM, NC

From the Department of Medicine, Durham Veterans Administration Hospital, Durham, NC. Present address: Department of Medicine, Yale University School of Medicine, New Haven, Conn.

Footnotes
Received for publication June 18, 1966; accepted July 1.

Reprint requests to the Department of Medicine, Yale University School of Medicine, New Haven, Conn.

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