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Acute Renal Failure Associated With Sodium Colistimethate Treatment
CHARLES M. ELWOOD, MD;
GORDON D. LUCAS, MD;
ROBERT C. MUEHRCKE, MD
Arch Intern Med. 1966;118(4):326-334.
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THE HE CURRENT medical literature reflects an increasing recognition of druginduced renal disease.1 The clinical effectiveness of the antibiotic, colistin, in a variety of bacterial infections has been well established.2-8 To date, disturbances of kidney function attributed to this drug have usually been minimal and completely reversible. This is a report of four patients in whom acute renal failure developed during treatment with sodium colistimethate (Coly-Mycin Injectable) (Table).
Report of Cases
Case 1 (Fig 1).
—B.I., a 75-year-old obese woman, was admitted to Presbyterian-St. Luke's Hospital for treatment of a fracture of the femur. On admission, the urinalysis was normal and the blood urea nitrogen (BUN) was 9 mg/100 ml. On the third hospital day, the head of the femur was replaced by a prosthesis. Low-grade fever was noted during the postoperative period. A small diffuse opacity of the right middle lobe of the lung was seen on
. . . [Full Text PDF of this Article]
Author Affiliations
CHICAGO; OAK PARK, ILL
From the departments of medicine, West Suburban Hospital, Oak Park, Ill (Dr. Muehrcke); Presbyterian-St. Luke's Hospital, Chicago (Dr. Lucas); and the University of Illinois Research and Education Hospitals, Chicago (Dr. Elwood). Dr. Elwood is presently with the Renal Unit, Buffalo General Hospital, Buffalo; and Dr. Lucas is presently at the Rockford Memorial Hospital, Rockford, Ill.
Footnotes
Received for publication April 12, 1966; accepted July 8.
Reprint requests to West Suburban Hospital, Oak Park, Ill (Dr. Muehrcke).
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