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Vacuolization of the NeutrophilAn Aid in the Diagnosis of Septicemia
PHILIP D. ZIEVE, MD;
MANSOUR HAGHSHENASS, MD;
MARY BLANKS;
JULIUS R. KREVANS, MD
Arch Intern Med. 1966;118(4):356-357.
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NEUTROPHILS in the blood of patients with infection frequently show degenerative changes including degranulation, swelling, pyknosis, toxic granulation, and vacuolization.1,2 It has been suggested that the extent of these alterations in the cell reflect the severity of disease in the patient.3
We have been impressed that vacuolization of the cytoplasm, in particular, is correlated with septicemia, and that examination of the peripheral blood may lead to the diagnosis of septicemia prior to bacteriologic confirmation. This report describes a prospective study designed to test this correlation.
Materials and Methods
Wright-stained smears of undiluted capillary blood were examined by technicians of the hematology laboratory on routine request from the ward physicians. The presence or absence of vacuolization of the cytoplasm of the neutrophils was noted during the course of a differential count of 100 leukocytes. The technicians were unaware of the clinical diagnosis.
Results
Approximately 3,500 smears were examined. Of
. . . [Full Text PDF of this Article]
Author Affiliations
BALTIMORE
From the departments of medicine of the Baltimore City hospitals and the John Hopkins University School of Medicine, Baltimore.
Footnotes
Received for publication April 15, 1966; accepted July 1.
Reprint requests to Baltimore City Hospitals, 4940 Eastern Ave, Baltimore 21224 (Dr. Zieve).
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