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Hypogammaglobulinemia With Late Development of LymphosarcomaCase Report
IRA GREEN, MD;
STEPHEN LITWIN, MD;
RADU ADLERSBERG, MD;
IRA RUBIN, MD
Arch Intern Med. 1966;118(6):592-602.
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THE ASSOCIATION of established chronic lymphatic leukemia or lymphosarcoma with hypogammaglobulinemia (HGG) is well known.1-3 The late development of a lymphosarcoma or leukemia in patients with clinically preexisting congenital or acquired hypogammaglobulinemia is a much rarer event. The purpose of this paper is to present the case of an adult patient with idiopathic acquired HGG of five years' duration, who was extensively studied during the period of HGG and who ultimately developed lymphosarcoma.
The occurrence of lymphosarcoma in patients with clinically preexisting HGG raises the question of the existence of common factors, which may link these two unusual diseases. Another interesting feature of this patient's disorder, that has not been previously reported, was that the tissues of this patient contained large amounts of  -globulin.
Report of Case
The patient was a 50-year-old white woman who was admitted to Montefiore Hospital for the first time in January 1957 because of
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
From the Department of Hematology, Laboratory Division, and the Medical Service, Montefiore Hospital and Medical Center, New York. Dr. Green is presently with the Department of Pathology, New York University School of Medicine, New York.
Footnotes
Received for publication July 11, 1966; accepted Sept 2.
Reprint requests to the Department of Pathology, New York University School of Medicine, 550 First Ave, New York 10016 (Dr. Green).
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