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NICHOLAS MANSOUR, MD; GORONWY O. BROUN, Jr., MD

Arch Intern Med. 1967;119(1):113-116.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE INCREASING use of chlorpromazine (CPZ) has led to an increasing awareness of its potential ability to cause agranulocytosis ^1-4 and the studies of Pisciotta and his co-workers have led to a better understanding of the mechanisms by which this toxic effect is produced.^5-8 By contrast, anemia, either hemolytic ^9,10 or aplastic, is a much rarer manifestation of the potential bone marrow toxicity of this agent. Aplastic anemia with pancytopenia has been reported in one case by Shelton et al ¹¹ and a total of 24 cases of this type of anemia following the administration of CPZ has been reported to the AMA Council on Drug Reactions.¹²

The mechanisms by which this drug might produce anemia have not been studied. It would seem unlikely that the abnormalities of deoxyribonucleic acid synthesis in leukocytes resulting from CPZ administration described by Pisciotta et al would only affect the single . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Department of Internal Medicine, St. Louis University School of Medicine and St. Louis University Hospitals, St. Louis.

Footnotes
Received for publication Aug 23, 1966; accepted Sept 16.

Reprint requests to the Department of Internal Medicine, St. Louis University School of Medicine, 1325 S Grand Blvd, St. Louis, Mo 63104 (Dr. Broun).

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