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Treatment by Massive Bronchopulmonary Lavage

Jose Ramirez-R, MD

Arch Intern Med. 1967;119(2):147-156.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PULMONARY alveolar proteinosis is characterized by the remittent or progressive accumulation of lipid-rich proteinaceous material within the alveolar sacs in the absence of inflammatory response.¹ The disease appears to be limited to the lung, although its association with rare and bizarre myeloproliferative syndromes suggests that its causative agent may also have a systemic effect.^2-4 Symptoms and findings are caused by a progressive interference with gaseous exchange or by superimposed bacterial and fungal infections.^3-5 The importance of alveolar cellular death in the pathogenesis of the disorder is supported by anatomical observations¹ and by the association of an elevated serum lactic acid dehydrogenase (SLDH) with active disease.^6-9

A new approach to the treatment of alveolar proteinosis was evolved in 1963, based on the concept that the disorder resulted from an abnormality of the pulmonary clearing process.⁶ Since that time, the successful treatment of seven cases by pulmonary segmental irrigation has been . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Medical Service, Veterans Administration Hospital and the Department of Medicine, the Johns Hopkins University School of Medicine, Baltimore.

Footnotes
Received for publication Aug 19, 1966; accepted Oct 17.

Read in part before the Annual Meeting of the American Thoracic Society, San Francisco, May 22-25, 1966.

Reprint requests to Veterans Administration Hospital, 3900 Loch Raven Blvd, Baltimore 21218 (Dr. Ramirez).

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