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Nicholas H. Maganias, MD; Louise Archambault, MS; Kenneth L. Becker, MD, PhD; John L. Winnacker, MD

Arch Intern Med. 1967;119(3):297-301.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In RECENT years, the relationship between congenital malformations and chromosomal abnormalities has been well established. The present paper describes a mentally retarded girl with multiple congenital anomalies and a 1/G translocation. In addition, five members of the kindred in three consecutive generations had an abnormal G chromosome.

Report of Case

A 5-year-old white girl was brought to our attention in August 1965 because of somatic and mental retardation. She was the product of a full-term gestation, weighing 8 lb 5 oz (3.8 kg). During the mother's pregnancy, occasional bleeding, infection of the external genitalia, and anemia were observed. The rest of the child's history was uneventful except for pneumonia at the age of 1 month and chronic asthma.

Physical examination revealed a slightly somatically retarded child (Fig 1) weighing 36 lb 4 oz (16.4 kg), within the sixth percentile, and with a height of 39 inches (100.3 cm), below the . . . [Full Text PDF of this Article]

Author Affiliations
Washington, DC

From the Veterans Administration Hospital and George Washington University, Washington, DC.

Footnotes
Received for publication July 26, 1966; accepted Oct 7.

Reprint requests to the Veterans Administration Hospital, 50 Irving St NW, Washington, DC 20422 (Dr. Maganias).

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