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Syphilis of the Great Epidemic? An Historical Review

Derek J. Cripps, MD; Arthur C. Curtis, MD

Arch Intern Med. 1967;119(4):411-418.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This REVIEW is concerned with syphilis maligna praecox, a rare form of secondary syphilis sometimes preceded by a phagedenic primary chancre. The more common course of syphilis¹ occurs initially with the occurrence of a primary chancre, an eroded indurated moist papule, usually within four weeks (10 to 90 days) of infection. The absolute diagnosis is made by finding the organism. Treponema pallidum (a positive dark-field), in the lesion or satellite lymph nodes. A presumptive diagnosis is made by a history of exposure and a rapidly rising serological titer. If syphilis has not been treated (4.8 million units of procaine penicillin in two divided doses), then the second stage appears two to six months after the initial infection. The clinical features of secondary syphilis are diverse; systemic symptoms such as malaise, fever, and arthralgias are usually trivial. The cutaneous lesions may assume various forms: macular, papular (often annular in shape), . . . [Full Text PDF of this Article]

Author Affiliations
Madison, Wis

From the Department of Dermatology, University of Wisconsin Medical Center, Madison, Wis (Dr. Cripps) and the University of Michigan Medical Center, Ann Arbor, Mich (Dr. Curtis).

Footnotes
Received for publication Aug 9, 1966; accepted Nov 23.

Reprint requests to 1300 University Ave, Madison, Wis 53706 (Dr. Cripps).

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