 |
|
Induced Intravascular Thromboembolic PhenomenaDirect Observation in the Living Extracorporeal Eye
Arthur J. Seaman, MD;
C. Lawrence Lutcher, MD;
Charlotte A. Moffat, MT;
Bonita E. Hueber, MT
Arch Intern Med. 1967;119(6):600-604.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
OUR EXPERIMENTAL preparation, "The Living Extracorporeal Eye,"1,2 permits us to examine thromboembolic phenomena intravascularly under microscopic magnification in the microcirculation of a living organ. Additionally, the composition of the oxygenated arterial blood supply is under our control and not altered by feedback mechanisms triggered by neurogenic or blood-borne signals.
In this paper we describe some of our initial attempts to define the sequence and components of thromboembolic phenomena obstructing the microcirculation. These include induced platelet aggregation, thrombin evolution produced by several techniques, and venous erythrothrombosis induced by intravascular hemagglutination. We have studied the influence of sodium heparin, sodium warfarin, and clinical dextran on these events. These phenomena are then related to the events observed when silicone-handled human blood without added anticoagulant is perfused intravascularly until clotting evolves spontaneously.
Methods and Materials
The living extracorporeal eye is a bovine eye enucleated immediately after slaughter. The ciliary artery is catheterized forthwith
. . . [Full Text PDF of this Article]
Author Affiliations
Portland, Ore
From the Coagulation Research Laboratory, Department of Medicine, University of Oregon Medical School, Portland.
Footnotes
Received for publication, June 1, 1966; accepted Dec 15.
Reprint requests to University of Oregon Medical School, 3181 SW Sam Jackson Park Rd, Portland, Ore 97201 (Dr. Seaman).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
